Women with half this gene variant (heterozygotes) who take estrogen forms of contraception have a 35-fold increased risk for developing a blood clot. This same patient on estrogen-based hormone replacement therapy has a 15-fold increase risk for developing a clot. The risk increases significantly more for homozygotes (those who carry the whole gene). And though smoking exacerbates the risk of developing a blood clot in any patient, that risk is multiplied in patients with Factor V Leiden.

In order for these patients to lower their risk of developing a blood clot, patients need to stay hydrated and remain mobile. Long periods of inactivity can exacerbate risk, so when faced with long car rides, trans-continental flights, or illnesses that confine one to the bed, patients should make an effort to get up and walk around every couple of hours (or at least consider wearing compression stockings during these times to aid circulation). These patients may also benefit from daily aspirin therapy.

Patients with this gene variant should notify all of their medical providers that they are carriers (particularly if they are pregnant or about to have surgery) because more aggressive anticoagulant therapy and monitoring may be necessary in certain circumstances.

Read more about Factor V Leiden HERE.

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