9p21 CVD Risk Genotype Test – “The Heart Attack Gene”

(Prevalence: 40%)

This genetic test helps identify individuals who may be at an increased risk of premature cardiovascular disease. Knowing this information can help the medical provider classify the patient’s cardiovascular risk more accurately, and implement more aggressive management of modifiable risk factors in appropriate patients.

The 9p21 gene has been shown to be an independent predictor of cardiovascular risk. Carriers have a 1.5-2.0 fold increased risk of cardiovascular disease (particularly stroke and abdominal aortic aneurysm) compared to non-carriers.

9p21

There are two possible 9p21 haplotypes, but each type confers a different type of cardiovascular risk.

Haplotype rs1333049 is associated with more severe multi-vessel obstructive coronary artery disease, though it is not associated with as many heart attacks.

Haplotype rs518394, on the other hand, is associated with prevalent heart attacks, but without significant stenosis (obstruction) of coronary arteries.

Do something today for a better tomorrow! 

Make an appointment now for advanced testing. We are here to help.

Advanced Genetic Tests

Click Below to Learn More

APO E
A gene that affects the way our body processes fat and alcohol, sometimes referred to as the "Alzheimer’s gene."

APO E

MTHFR
A gene that affect the body’s ability to detoxify and utilize certain B vitamins (which affect brain, heart, and infant health).

MTHFR

SLOCO1B1
A gene that can identify who is at increased risk of having side effects from statin cholesterol drugs.

SLOCO1B1

KIF 6
A gene that increases the risk of heart disease, but can determine who would particularly benefit from statin cholesterol medications

KIF 6

9P21
A gene that can identify individuals who may be at an increased risk of premature heart disease.

9P21

4Q25
A gene that can identify who is at increased risk of developing atrial fibrillation (a potentially dangerous arrhythmia of the heart).

4Q25

Prothrombin Mutation
A gene that increases the risk of developing blood clots

Prothrombin Mutation

Factor V Leiden
A gene that increases the risk of developing blood clots

Factor V Leiden

CYP2C19
A gene that determines if the blood thinner Plavix is metabolized normally, or whether this medication could lead to increased clotting or bleeding.

CYP2C19

Advanced Genetic Tests

Click Below to Learn More

APO E
A gene that affects the way our body processes fat and alcohol, sometimes referred to as the "Alzheimer’s gene."

APO E

MTHFR
A gene that affect the body’s ability to detoxify and utilize certain B vitamins (which affect brain, heart, and infant health).

MTHFR

SLOCO1B1
A gene that can identify who is at increased risk of having side effects from statin cholesterol drugs.

SLOCO1B1

KIF 6
A gene that increases the risk of heart disease, but can determine who would particularly benefit from statin cholesterol medications

KIF 6

9P21
A gene that can identify individuals who may be at an increased risk of premature heart disease.

9P21

4Q25
A gene that can identify who is at increased risk of developing atrial fibrillation (a potentially dangerous arrhythmia of the heart).

4Q25

Prothrombin Mutation
A gene that increases the risk of developing blood clots

Prothrombin Mutation

Factor V Leiden
A gene that increases the risk of developing blood clots

Factor V Leiden

CYP2C19
A gene that determines if the blood thinner Plavix is metabolized normally, or whether this medication could lead to increased clotting or bleeding.

CYP2C19

REFERENCES

1 – He Y, Li Y, Chen Y, Feng L, Nie Z. Homocysteine level and risk of diff erent stroke types: a meta-analysis of prospective observational studies. Nutr Metab Cardiovasc Dis. 2014;24(11):1158-1165.

 

2 – Li P, Qin C. Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and susceptibility to ischemic stroke: a meta-analysis. Gene. 2014;535(2):359-364.

 

3 - Zhang MJ, Hu ZC, Yin YW, et al. A meta-analysis of the relationship between MTHFR gene A1298C polymorphism and the risk of adult stroke. Cerebrovasc Dis. 2014;38(6):425-432.

 

4 – Kang S, Wu Y, Liu L, Zhao X, Zhang D. Association of the A1298C polymorphism in MTHFR gene with ischemic stroke. J Clin Neurosci. 2014;21(2):198-202.

 

5 – Saposnik G, Ray JG, Sheridan P, McQueen M, Lonn E; Heart Outcomes Prevention Evaluation 2 Investigators. Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial. Stroke. 2009;40(4):1365-1372.